“See you in heaven one day” is a line from one of my dad’s all-time favorite songs, which I have recently been revisiting. By 2020, my dad had been in nursing homes for almost six years, suffering from late-stage Huntington’s disease. He’d been having…
Note: This story was updated Jan. 24, 2024, to correct that Takeda is not supporting WVE-003’s development. Wave Sciences is the treatment’s sole developer; Takeda has a codevelopment and co-commercialization option. New data from a Phase 1/2 trial of WVE-003, a therapy targeting the mutant huntingtin protein in people…
As I descended a country lane through the valley this morning on my way to work, storm clouds that had gathered began to clear, revealing a blue sky. Daffodil sprouts appeared in the hedgerows. The sun shone across the fields, highlighting the remaining autumnal colors, and then streamed through the…
Neurologists in the U.S. are optimistic about the potential for a new treatment for Huntington’s disease, but emphasize the need for therapies that halt nerve degeneration before symptom onset, according to a report by Spherix Global Insights. Most of the specialist physicians surveyed hoped for a gene therapy…
During a recent walk in our neighborhood, my wife, Jill, and I admired the colors of the leaves on the trees while enjoying the mild winter weather we’ve been experiencing. We talked about our love-hate relationship with trees, leaves, and yardwork, and how Huntington’s disease progression affects…
My brother, Gavin, was diagnosed with Huntington’s disease in January 2022, at the age of 42. The disease took our dad’s life in May 2020, when he was 68. So far, it has affected four generations of our family. As we enter a new year, I’m reflecting…
In 2023, Huntington’s Disease News brought you the latest in scientific breakthroughs and treatment developments related to Huntington’s disease. To recap what interested our readers most this year, here are the top 10 most-read articles, with a brief description of each. We look forward to serving as a…
People with Huntington’s disease have significantly higher levels of the proinflammatory molecule interleukin-6 (IL-6) and the anti-inflammatory molecule IL-10 in their blood relative to healthy people, according to a review study. The IL-6 difference was true for both pre-manifest patients — those carrying Huntington’s-causing mutations, but not yet having…
My dad spent the last four years of his life in the Warberries Nursing Home in Torquay, Devon, England, suffering from Huntington’s disease. He’d been moved there when his ability to swallow and his speech had deteriorated. The building was a Victorian Grade…
Rumi Scientific has joined with X-Chem to advance in early development a suppressor, or inhibitor, of bromodomain-containing protein 9 (BRD9) as a possible Huntington’s disease treatment. “BRD9 inhibition is a novel target for the treatment of HD [Huntington’s disease] identified by our proprietary high…
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