Author Archives: Steve Bryson PhD

Huntington’s Protein Clumps Form Distinct Structures in Nerve Cells

Clumps of protein resulting from HTT mutations, the underlying cause of Huntington’s disease, form distinct structures in different parts of the cell, according to detailed imaging analysis. The findings suggest these clumps form by different mechanisms and may require different therapeutic strategies to block their formation and toxicity that…

Study Links Cognitive Impairment to Reduced Gray Matter Volume

Based on MRI scans, Huntington’s disease patients with major cognitive impairments have reduced gray matter volume and a thinner brain cortex than those without cognitive problems, a study has demonstrated.  Major cognitive decline was not associated with CAG repeat length, age, or education, suggesting additional…