Author Archives: Alice Melão

#AAN2018 – IONIS-HTTRx Shows Promise in Phase 1/2 Trial to Treat Early-stage Huntington’s

The investigative therapy IONIS-HTTRx effectively reduced levels of the protein responsible for Huntington’s disease in early-stage patients, according to the findings of an ongoing Phase 1/2 clinical trial. The results also revealed that IONIS-HTTRx is generally safe and well-tolerated by patients, further demonstrating its potential as an alternative therapeutic option…

HTT Mutations Seen to Cause Extensive Brain Remodeling, Affecting Motor and Cognitive Skills

Mutations linked to Huntington’s disease cause more extensive remodeling of functional connectivity in various regions of the brain than previously thought, affecting patients’ motor and cognitive skills, research looking at whole brain connectivity in disease carriers reports. These findings — in “Whole-Brain Connectivity in a Large Study of Huntington’s…

Huntington’s Patients’ Skin Cells Transformed Into Nerve Cells That Mimic Disease Symptoms

Nerve cells that mimic the molecular features of Huntington’s disease have been created from patients’ skin cells, researchers said. The study, “Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes,” was published in Nature Neuroscience. These engineered nerve cells exhibit many of…

Researchers Review Role of Manganese in Huntington’s Disease Development

The chemical compound manganese (Mn) has been reported to take part in the underlying mechanism of Alzheimer’s disease. However, little is known about its involvement in the development of other neurodegenerative diseases. In the study titled “Manganese in manganism, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and…

Plant Study Reveals Mechanism That May Explain Protein Folding in Human Disease

A Spanish study investigating the functioning of chloroplasts — the nutrient-producing “factory” of plants — has revealed a new mechanism that helps understand how a cell controls and regulates protein folding mechanisms. This new finding can improve knowledge of Huntington’s disease and other neurodegenerative disorders such as Alzheimer’s and Parkinson’s…