Author Archives: Alice Melão

AC Immune Identifies Antibodies Against the Alpha-Synuclein, TDP-43 Proteins Linked to Huntington’s

AC Immune has identified antibodies that target the alpha-synuclein and TDP-43 proteins associated with neurodegenerative diseases such as Huntington’s. The discovery could be used to develop treatments for such diseases, the company said. Antibodies are immune system cells that can recognize and generate a response to invaders. “Many neurodegenerative diseases share…

How Mutant Protein Drives Cellular Toxicity in Huntington’s Revealed in Study

Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms of mutated huntingtin are actually responsible for major molecular changes in cells that will drive toxicity. The study, “Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon…

Researchers Discover Why Defects Form in Blood Brain Barrier of Huntington’s Patients

Researchers have discovered why Huntington’s disease (HD) patients have defects in the blood-brain barrier that contribute to the symptoms of this neurological disorder. Their study, “Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits,” was published in Cell Reports. “Now we know there are…