Posts by: Alice Melão

News

Identifying Huntington’s disease progression can be a challenge in clinical trials. Now, an international team of researchers proposes in an article published in JAMA Neurology the use of a new ... Read more

September 28, 2017

NIH Grant Supports Development of HDWear System to Monitor Motor Function Remotely

News

The National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) has awarded a grant of more than $2.5 million to support the development ... Read more

August 29, 2017

AC Immune Identifies Antibodies Against the Alpha-Synuclein, TDP-43 Proteins Linked to Huntington’s

News

AC Immune has identified antibodies that target the alpha-synuclein and TDP-43 proteins associated with neurodegenerative diseases such as Huntington’s. The discovery could be used to develop treatments for such diseases, the ... Read more

August 17, 2017

How Mutant Protein Drives Cellular Toxicity in Huntington’s Revealed in Study

News

Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms of mutated huntingtin are actually responsible for major molecular changes ... Read more

July 11, 2017

Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms

News

A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated with disease severity in Huntington’s patients, while a higher metabolism ... Read more

June 8, 2017

Cell Transport ‘Traffic Jam’ Caused by Mutated Protein, Researchers Discover

News

A mutated form of the huntingtin (mHTT) protein has been acknowledged as the cause of Huntington’s disease, but researchers have not been fully clear about how it disrupts the ... Read more

June 1, 2017June 1, 2017

Researchers Identify a Key Link Between the Brain’s Immune Cells and Neurodegenerative Disorders

News

Researchers at the University of California and the Salk Institute for Biological Studies have identified the mechanisms that make the brain’s immune cells different from all other immune cells A ... Read more

May 30, 2017

Researchers Find Common Disease Processes in Huntington’s, Alzheimer’s and Parkinson’s

News

Abnormal proteins found in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s seem to rely on the same mechanism to spread within the brain and disrupt its normal functions, ... Read more

May 23, 2017

University of Sussex Researchers Receive $3.37 Million to Develop Huntington’s Treatments

News

Researchers at the Sussex Drug Discovery Centre in Brighton, England, have received a £3 million grant from Britain’s non-profit Wellcome Trust to develop Huntington’s disease treatments. The team will team up with other ... Read more

May 18, 2017

Researchers Discover Why Defects Form in Blood Brain Barrier of Huntington’s Patients

News

Researchers have discovered why Huntington’s disease (HD) patients have defects in the blood-brain barrier that contribute to the symptoms of this neurological disorder. Their study, “Huntington’s Disease iPSC-Derived Brain ... Read more