“In sickness and in health, for as long as we both shall live.” These words took on deeper meaning for our family recently after I underwent genetic testing for Huntington’s disease. Huntington’s disease took our dad’s life in May 2020, and my brother, Gavin, was…
Two types of orally available small molecules ameliorated symptoms and slowed progression of Huntington’s disease in a mouse model, a study reported. The treatments effectively reduced the levels of the mutant huntingtin protein in the brain without affecting normal huntingtin. The mutant version causes Huntington’s, a neurodegenerative condition.
As regular readers of this column know, I love my wife, Jill, with all my heart. I love her simplicity. I love her sense of humor. And of course, I love that she’s the mother of our wonderful daughter, Alexus. Still, I have to admit…
“It’s your road, and yours alone. Others may walk it with you, but no one can walk it for you.” — Rumi, scholar and poet Huntington’s disease has so far affected four generations of our family. We lost our dad to Huntington’s in May 2020 and…
A first clinical trial of SKY-0515, an experimental treatment for Huntington’s disease, is starting to give multiple ascending doses to healthy adults randomized to the therapy rather than a placebo, Skyhawk Therapeutics, its developer, announced. Initiation of this part of the Phase 1 trial (ACTRN12623001161617), taking place in…
If I were to ask people what’s due on April 15, most would say “taxes.” In my 15 years of marriage to my wife, Jill, I haven’t had to worry about that deadline before. Filing our taxes has been Jill’s job, as she’s always been able to read…
“Of all base passions, fear is most accursed.” — Joan La Pucelle (Joan of Arc), in Shakespeare’s “King Henry VI, Part I” Huntington’s disease has taken the lives of my dad, grandfather, and great-grandmother. My brother, Gavin, was diagnosed with it in January 2022, at the age…
The brain of people with pediatric-onset Huntington’s disease show impaired transport of blood sugar, or glucose, and low levels of a cellular machinery involved in glucose metabolism, a small study showed. Many of these abnormalities were observed in comparisons not only with adults without Huntington’s, but also with people with…
When, on a recent Friday night after I’d worked a 60-hour week, my wife, Jill, asked me if I wanted to go to breakfast the next morning, my first instinct was to say no. Instead, I said I’d love to go. The reason was simple: I love Jill…
“All body systems would be immobilized without the nervous system. It controls and regulates every bodily activity down to the workings of the tiniest cell.” — World Book Encyclopedia of Science Because Huntington’s disease (HD) damages neurons, or nerve cells, in the brain, it can cause a variety of…
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