We’re now halfway through our summer here in the U.K., but you wouldn’t necessarily know it this year. Only last week, I needed to wear jumpers and tights because of unseasonably chilly temperatures. We’ve been lacking much summer sunshine as we’ve had higher than average rainfall. This week, however, has…
An investigational oral therapy from PTC Therapeutics called PTC518 safely and effectively reduces levels of the mutant huntingtin protein (mHTT) in Huntington’s disease patients, while being linked to trends of slower disease progression. That’s according to one-year interim data from the ongoing Phase 2a PIVOT-HD clinical trial…
As a father, I’ve had many moments when I was proud of my daughter, Alexus. I’m proud of her love of helping others; of her acceptance into one of the top schools in the world, the Massachusetts Institute of Technology; of how deeply she loves to enjoy life.
“A friend is someone who knows all about you and still loves you.” — Elbert Hubbard Huntington’s disease has affected several generations of my family, taking the lives of my dad, granddad, and great-grandmother. I tested negative for the disease in the summer of 2023. In the…
Significant impairments in cognitive function are evident in people with Huntington’s disease relative to healthy adults, as assessed with a disease-specific battery of cognitive tests, top-line data from a Phase 2 clinical trial show, meeting its main goal. The two-part trial, called SURVEYOR (NCT05358821), also evaluated the safety…
A Pollyanna is someone who maintains an optimistic perspective, even in the face of difficult situations. As a cup-half-full kind of guy, I like being positive. However, it’s essential to find balance, especially when dealing with mental health or other significant issues. Toxic positivity can be naive…
“When it started getting bad, it was like watching her drown.” That’s how a young man named Morgan described watching his mother’s Huntington’s disease (HD) progress. His interview was part of a video created by the Huntington’s Disease Youth Organization (HDYO) about the condition’s impact on young…
The effects of Ingrezza (valbenazine) on Huntington’s disease-associated chorea grew increasingly stronger over the course of the three-month Phase 3 KINECT-HD clinical trial, according to a post-hoc analysis. A post-hoc analysis is one planned and conducted after the trial has been completed. “This post-hoc analysis of the…
Fifteen years of marriage have taught me that compromise and understanding remain at the heart of a strong relationship. These elements have become more important since Jill’s diagnosis of Huntington’s disease in 2018. As I reflect on our life since then, I realize how much we have grown individually…
Clinical trials testing either tominersen, an experimental therapy designed to target the underlying cause of Huntington’s disease, or dalzanemdor, an oral candidate that aims to improve cognitive abilities, are currently enrolling Huntington’s patients in the U.S. Updates on the therapies’ clinical programs were provided by representatives of their…
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