Unlike its healthy counterpart, the mutated version of the huntingtin protein that drives Huntington’s disease may keep nerve cells from repairing their damaged DNA, causing them to die, a study showed. Specifically, the mutated protein failed to stimulate the production of poly ADP-ribose, known as PAR — a molecule…
My wife, Jill, and I often find ourselves in airports with free time while visiting family across the country. To escape the chaos in waiting areas, we often watch TV shows on my iPad. Recently, we finished HBO’s “Succession,” a drama about a global media…
One of the most challenging aspects of living with Huntington’s disease (HD) is coming to terms with the progressive nature of the condition and the inevitable changes it brings. For those of us who are symptomatic, that involves not only adapting to physical and cognitive changes, but…
In Huntington’s disease (HD), progression is associated with metabolite changes in the brain that generally worsen as patients move from a presymptomatic stage to overt symptom onset, a review study reports. Its scientists looked at data from published studies analyzing metabolic changes in the brain between people with Huntington’s…
As someone whose wife and daughter are gene-positive for Huntington’s disease (HD), I’m always interested in any new studies and advancements in treatment. So when a friend recently called to let me know that the Huntington’s Disease Society of America (HDSA) is hosting a meeting in November…
My name is Tanita Allen, and in 2012, I received life-changing news: I was diagnosed with Huntington’s disease (HD), a rare, neurodegenerative condition. Huntington’s is rare enough as it is, but the belief that it doesn’t affect people of African descent made getting a proper diagnosis even…
Vico Therapeutics’ investigational therapy VO659 was found to lower levels of the disease-causing mutant huntingtin (HTT) protein — known as mHTT — in the cerebrospinal fluid (CSF), the liquid that surrounds the brain and spinal cord, of people with Huntington’s disease. Additionally, treatment was not associated with an…
Halloween is coming next month. It’s my wife Jill’s favorite holiday, mainly because she likes scary experiences. Her excitement is like a child’s when she enters a haunted house or steps onto a roller coaster. There’s something about the rush — that heart-pounding excitement — that makes her fearless…
When I answered a Facebook post in a Huntington’s disease (HD) community support group, little did I know what kind of a journey it would take me on. Fellow colleague and columnist B.J. Viau was looking for someone who might be interested in writing a column for…
The European Medicines Agency (EMA) has agreed to review Prilenia Therapeutics’ application seeking approval of pridopidine, an oral therapy candidate for adults with Huntington’s disease, the company announced. The regulatory application is based on safety and efficacy data from pridopidine’s clinical development program, which showed the therapy…
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