Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

March 5, 2018April 5, 2018

Tracking Nerve Cells’ Signaling-protein Delivery Is Shedding Light on Huntington’s

News

Nerve cells contain proteins that send signals to other cells and proteins that receive neighboring cells’ signals. Researchers at Rensselaer Polytechnic Institute in Troy, New York, are trying to understand ... Read more

January 18, 2018January 18, 2018

uniQure Aims to Begin First Human Trial of Investigational Gene Therapy AMT-130 for Huntington’s in 2018

News

uniQure expects to advance the clinical development of its Huntington’s disease investigational gene therapy, called AMT-130, during 2018. The company says it plans to file an investigational new drug application (IND) ... Read more

December 19, 2017

Too Much Urea in Brain May Underlie Huntington’s Disease Progression, Study Shows

News

Aberrant metabolism of urea is a potential first event promoting Huntington’s disease (HD), a study with a sheep model and human brain samples showed. The findings suggest that lowering ... Read more

November 21, 2017November 21, 2017

Rilmenidine Well-Tolerated in HD Patients, but More Studies Needed, Researchers Say

News

Researchers have found that rilmenidine, a blood pressure medicine, was relatively safe and well-tolerated by Huntington’s disease (HD) patients in a small study. However, its effectiveness in treating the disease ... Read more

November 2, 2017

Researchers Identify Mechanism to Prevent Toxic Accumulation of Proteins in Mitochondria

News

Researchers have identified an elaborate protein quality control system that prevents toxic accumulation of faulty proteins inside mitochondria, a phenomenon that underlies many neurodegenerative diseases, including Huntington’s disease. The ... Read more

October 31, 2017

Natural Compounds May Carry Therapeutical Benefits for Huntington’s

News

As therapeutics for Huntington’s disease (HD) are still a need, a number of natural compounds may hold promising beneficial effects, a review study shows. The review “The Medicinal Chemistry ... Read more

September 5, 2017September 5, 2017

Huntington’s Causes Hearing Problems, Study with a Small Sample Size Suggests

News

Huntington’s disease causes hearing problems, a study with a small sample size suggests. The research, “Auditory dysfunction in patients with Huntington’s disease,“ was published in Clinical Neurophysiology. A severe, ... Read more

August 31, 2017August 31, 2017

Researchers Create New Cell Model to Study Functions of Mutant Protein in Huntington’s

Huntington's Disease News, News

Researchers generated the first human line of Huntington’s disease induced pluripotent stem cells (iPSCs) that do not express the dysfunctional protein underlying the condition. The cells represent a potential ... Read more

August 1, 2017

Using Gene Editing to Suppress Activity of Protein Mutations Could Be Way to Treat Huntington’s, Study Reports

News

Researchers used gene editing to suppress the activity of protein mutations in the brains of mice with Huntington’s disease. Suppressing the huntingtin protein alleviated early signs of the disease ... Read more

April 13, 2017

Results of Probiodrug AG Mouse Study to be Presented at HD Therapeutics Conference

News

Probiodrug AG recently announced the results of a preclinical study investigating the role of glutaminyl cyclases (QCs) in Huntington’s disease. The results will be presented at the 12th Annual HD ... Read more

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