Author Archives: Patricia Inacio PhD

Biomarker Platform That May Track Huntington’s Decades Before Symptom Onset Receives FDA Letter of Support

The U.S. Food and Drug Administration (FDA) has issued a letter of support encouraging sRNAlytics to further develop its sRNA-FIND platform for discovering and monitoring variants of small RNA molecules that may work as biomarkers for tracking progression of Huntington’s disease decades before symptom onset. In addition, these biomarkers may…

Fast Screening Strategy Identifies Potential New Inhibitors for Huntington’s Disease

Several small molecules have been identified by the Alborada Drug Discovery Institute as potential inhibitors to help halt the underlying mechanisms that drive the development of neurodegenerative diseases such as Huntington’s and Parkinson’s disease. Silencing phosphatidylinositol 5-phosphate 4 (PI5P4) kinases has been shown to enhance the natural cleaning system of cells, called autophagy,…

Compound in Raspberries May Help Protect Against Huntington’s, Other Neurodegenerative Diseases, Study Says

A bioactive compound present in raspberries called salidroside can prevent the cellular toxicity that occurs as a consequence of protein accumulation in certain neurodegenerative diseases, including Huntington’s disease, a study reports. The study, “Identification and microbial production of the raspberry phenol salidroside that is active against Huntington’s disease,” was published…

Protein May Help Prevent Nerve Cell Death in Huntington’s Disease

Researchers have found a protein, called UBR5, that may reduce neurodegeneration in Huntington’s disease (HD). This protein prevents the toxic aggregation (clustering) of mutant huntingtin protein, which is the underlying mechanism that triggers nerve cells’ death in Huntington’s patients. The study, “The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent…

Retrotope’s RT001 Reduced Cognitive Defects in Mice with Huntington’s Disease, Study Shows

Retrotope’s investigative therapy RT001 reduced cognition deficits in  mice with Huntington’s disease, and was found to lower the amount of oxidative damage in their brains. The study, “Deuterium‐reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington’s disease,” was published in…