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San Diego-based Molecular Stethoscope, a company that develops blood-based early detection and disease monitoring tests, is partnering with 23 national medical and academic institutions to address some of the most puzzling scientific questions about disease diagnosis and monitoring. The company has developed clinically actionable tests that analyze organ-specific circulating…

Lithium may be effective to eliminate suicidal symptoms in patients with Huntington’s disease (HD), according to a study titled “Huntington’s disease and suicidal behavior: The importance of lithium treatment,” published in the journal Clinical Neurology and Neurosurgery. Huntington’s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination…

Scientists at Boston Children’s Hospital have revealed the cellular and biological mechanisms involved in synapse loss in Alzheimer’s disease. By blocking certain agents involved in this process, scientists could halt synaptic loss, a discovery with therapeutic potential not only for Alzheimer’s, but also other diseases with loss of neuronal connections, including Huntington’s disease. The…

uniQure recently published results from preclinical studies of its gene therapy program, AMT-130, indicating that a one-time administration of AAV5-delivered therapy into the central nervous system can block the mutant HTT gene that causes Huntington’s disease (HD). These findings, in the article “Design, Characterization, and Lead Selection of Therapeutic miRNAs…