News

Basic Brain Research into Nerve Development Hints at Mechanisms in Huntington’s

Two scientists at Cambridge University used differing techniques to better understand how brain cells form connections, research that may inspire new ways of rewiring the brain to repair nerves and treat diseases such as Huntington’s. Professor Christine Holt of the Department of Physiology, Development and Neuroscience, focused on how molecules influence neurons…

Protein Plaques in Huntington’s Patients Have Distinct Structures That Hint at Disease Mechanisms

Researchers found that the mutant huntingtin protein aggregates characteristic of Huntington’s disease have distinctive structural features, a discovery that might help to uncover the disease’s underlying mechanisms and lead to new therapies. The study, “Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core,” was published in Proceedings of the National…

Molecule Seen to Ease Neuronal Damage Caused by Huntington’s Mutation

Texas Tech University Health Sciences Center researchers have identified a molecule that might have protective effects against neuronal damage caused by mutant huntingtin, and constitute a potential therapeutic target for the treatment of Huntington’s disease. The study, “Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics, synaptic dysfunction…

Huntington’s Researcher Among 2016 Harrington Scholar-Innovator Award Winners

The Harrington Discovery Institute at University Hospitals (UH) in Cleveland, Ohio, recently announced the 2016 recipients of its Harrington Scholar-Innovator Awards, given in support of physician-scientists whose discovery research holds promise in advancing the standard of patient care. Among this year’s winners is Stanley N. Cohen, MD, from Stanford University, who received $700,000…

Huntington’s Gene-inducing Damage Might Have a Control Mechanism

Texas Tech University Health Sciences Center (TTUHSC) researchers have identified a molecule — mitochondrial division inhibitor 1 (Mdivi1) — believed to hold promise as a potential treatment for Huntington’s disease. Mitochondria are specialized organelles in a cell responsible for creating the energy needed by the body to sustain life. An…

Huntingtin Protein’s Mechanisms of Action Seen in Study

Max Planck Institute of Biochemistry researchers have shown that the intracellular location of protein aggregates, long suspected to be involved in the pathogenesis of neurodegenerative diseases like Huntington’s, is extremely important to the survival of nerve cells. While location in the nucleus has little influence on cellular function, protein deposits in the…