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Dosing Starts in SELECT-HD Trial That Seeks to Lower mHTT Levels

A Phase 1/2 trial evaluating Wave Life Science’s investigational therapy WVE-003 for Huntington’s disease has started dosing patients, the company has announced. The SELECT-HD trial (NCT05032196), underway in clinical sites in Australia, Germany, Poland, and the U.K., is currently looking to enroll 36 Huntington’s patients, ages…

Abnormal DNA Repair Mechanism May Be Therapeutic Target

The interaction between FAN1 and MLH1 — two DNA repair proteins known to be genetic modifiers of Huntington’s disease — protects against further expansion of disease-causing CAG repeats, according to a study using human and mouse models of the disease. Specifically, this interaction prevents MLH1’s recruitment to a DNA…

Wondering About ADHD and Huntington’s

Earlier this year, I wrote that I was dealing with attention deficit hyperactivity disorder (ADHD), but didn’t realize it until my wife, Jill, pointed it out to me. Today, with her permission, I’m turning the spotlight on her. My wife has always admitted that she suffers from ADHD,…

Handling Life’s Fragility With Care

In late July, before my nephew, Dylan, moved to the Georgian capital of Tbilisi, in the Caucasus region, for several months, I played several songs for him while we were in his car. One of them was a live version of “Fragile” by Sting. I know Dylan’s taste…

We Need Realistic Timelines for Huntington’s Treatments

Getting a new treatment to people with rare conditions like Huntington’s disease is difficult. It takes lots of intelligence about a specific topic and immense time and energy. It requires funding to fuel the time and energy of those intelligent people. It depends upon a correct hypothesis that is executed…

My Wife’s Family Is Huntington’s Strong

Huntington’s is a strange and deadly disease. It’s not like cancer. Only 5-10% of cancer is hereditary, and what’s passed down is the abnormal gene that can lead to cancer, not the cancer itself. It’s not like heart disease. Certain risk factors, such as high cholesterol, can be…