Author Archives: Marta Figueiredo PhD

Huntington’s Alters Brain Development Before Birth, Study Shows

Huntington’s disease alters nerve cell development in the cortex — a brain region largely affected in people with the condition — before birth, a study has found. “Huntington’s definitely has a neurodevelopmental component in addition to a neurodegenerative disease,” Sandrine Humbert, PhD, the study’s senior author at the…

Microprotein of Mitochondria Helps Regulate Protein Folding and Cell Stress Linked to Disease, Study Finds

PIGBOS — a newly discovered mitochondrial microprotein involved in a cellular stress-response mechanism called unfolded protein response (UPR) — might be a treatment target for neurodegenerative diseases like Huntington’s, a study suggests. The study, “Regulation of the ER stress response by a mitochondrial microprotein,” was published…