A Genetic Lottery
— Rebecca Field

UCB and Baylor College of Medicine have announced a strategic research alliance to discover therapies for people with neurodegenerative conditions, such as Huntington’s disease (HD). The research effort will be conducted by Dr.

Researchers have for the first time visualized the structure of the protein α-synuclein in healthy living cells, allowing a better understanding of why the protein forms aggregates in Huntington’s disease (HD) and other neurodegenerative…

Two scientists at Cambridge University used differing techniques to better understand how brain cells form connections, research that may inspire new ways of rewiring the brain to repair nerves and treat diseases such as Huntington’s. Professor…

A research team successfully developed a virus variant that is more efficient than the current standard at crossing the blood-brain barrier and delivering genes to the central nervous system (CNS), making it a promising…

Texas Tech University Health Sciences Center researchers have identified a molecule that might have protective effects against neuronal damage caused by mutant huntingtin, and constitute a potential therapeutic target for the treatment of Huntington’s disease.

Texas Tech University Health Sciences Center (TTUHSC) researchers have identified a molecule — mitochondrial division inhibitor 1 (Mdivi1) — believed to hold promise as a potential treatment for Huntington’s disease. Mitochondria are specialized organelles…

Neuropsychiatric symptoms of depression and irritability or aggression are associated with alterations in the white matter structure of the brains of early-onset Huntington’s disease (HD) patients. These are the results of a recent study titled…

A study with a small cohort of Huntington’s disease patients differed from previous research in finding no metabolic alterations associated with disease progression in stage 2/3 patients compared to both premanifest and healthy subjects. The study,…

Max Planck Institute of Biochemistry researchers have shown that the intracellular location of protein aggregates, long suspected to be involved in the pathogenesis of neurodegenerative diseases like Huntington’s, is extremely important to the survival of nerve…

Using a fruit fly model of Huntington’s disease (HD), researchers found that curcumin – a substance in the spice turmeric– can reduce neuronal death and dysfunction and lead to better motor function in flies.

Ionis Pharmaceuticals, Inc. — formerly Isis Pharmaceuticals — announced the U.S. Food and Drug Administration (FDA) has approved its Orphan Drug Designation application for IONIS-HTTRx as a potential treatment of Huntington’s disease (HD). Ionis’ IONIS-HTTRx is a generation 2.0+…

VistaGen Therapeutics, Inc., a clinical-stage biopharmaceutical company advancing treatments for depression, cancer, and diseases like Huntington’s that involve the central nervous system, announced that it has secured exclusive worldwide commercial rights to three patent-pending stem-cell technologies…