August 22, 2017August 22, 2017
Identification of Huntington’s Disease Progression Gene Raises Hope of New Treatments
News
Researchers in England and Wales have identified a gene linked to disease progression in Huntington’s disease, shedding new light ... Read more
August 17, 2017
How Mutant Protein Drives Cellular Toxicity in Huntington’s Revealed in Study
News
Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms ... Read more
August 15, 2017August 15, 2017
UniQure Plans Tests That Could Lead to Clinical Trial of AMT-130 Gene Therapy for Huntington’s
News
Dutch pharmaceutical company uniQure says it plans to conduct preclinical studies leading to clinical testing of a gene therapy in patients ... Read more
August 1, 2017
Using Gene Editing to Suppress Activity of Protein Mutations Could Be Way to Treat Huntington’s, Study Reports
News
Researchers used gene editing to suppress the activity of protein mutations in the brains of mice with Huntington’s disease. ... Read more
July 27, 2017
Reducing HDAC3 Protein Levels Can Stop Cognitive Decline Associated with Huntington’s Disease, Study Says
News
Therapies aimed at reducing the levels of a protein called HDAC3 may improve cognitive decline in Huntington’s disease, according ... Read more
July 25, 2017
Brain Receptor Caught in Action May Help Researchers Find New Huntington’s Treatments
News
A snapshot of a key brain receptor in action might advance the understanding of disease processes in Huntington’s disease ... Read more
July 20, 2017July 20, 2017
New Research Data Network Aims to Advance Discovery of Huntington’s Treatment
News
Researchers have created the first freely available data network — called HDNetDB — that aims to advance research into ... Read more
July 18, 2017
Wave Life Sciences to Start Trials of Two Therapies That Target Huntington’s Mutations
News
Wave Life Sciences will start two Phase 1b/2a clinical trials to investigate the safety and tolerability of its products ... Read more
July 13, 2017
People with Chorea Can Switch from Xenazine To Austedo Safely, Phase 3 Clinical Trial Shows
News
Huntington’s patients who are taking Xenazine for the twitching condition known as chorea can switch without concern to the newly approved ... Read more
July 11, 2017
Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms
News
A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated ... Read more
July 6, 2017
MSH3 Gene Mutations May Be Involved in Huntington’s Disease Progression, Study Finds
News
Mutations of the MSH3 gene may be associated with the progression of Huntington’s disease, according to a British study. ... Read more
June 29, 2017
Mitoconix Bio Obtains $20 Million To Continue Developing Huntington’s Therapy MTC-1203
News
Mitoconix Bio has secured $20 million in financing to continue developing MTC-1203 as a treatment for mitochondrial impairment in Huntington’s ... Read more

Identification of Huntington’s Disease Progression Gene Raises Hope of New Treatments

Researchers in England and Wales have identified a gene linked to disease progression in Huntington’s disease, shedding new light on the poorly understood mechanisms that cause the disorder. Although ... Read more

August 17, 2017

How Mutant Protein Drives Cellular Toxicity in Huntington’s Revealed in Study

News

Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms of mutated huntingtin are actually responsible for major molecular changes ... Read more

August 15, 2017August 15, 2017

UniQure Plans Tests That Could Lead to Clinical Trial of AMT-130 Gene Therapy for Huntington’s

News

Dutch pharmaceutical company uniQure says it plans to conduct preclinical studies leading to clinical testing of a gene therapy in patients with Huntington’s disease. The company is developing AMT-130, an experimental therapy ... Read more

August 1, 2017

Using Gene Editing to Suppress Activity of Protein Mutations Could Be Way to Treat Huntington’s, Study Reports

News

Researchers used gene editing to suppress the activity of protein mutations in the brains of mice with Huntington’s disease. Suppressing the huntingtin protein alleviated early signs of the disease ... Read more

July 27, 2017

Reducing HDAC3 Protein Levels Can Stop Cognitive Decline Associated with Huntington’s Disease, Study Says

News

Therapies aimed at reducing the levels of a protein called HDAC3 may improve cognitive decline in Huntington’s disease, according to the results of a new study. The study titled, ... Read more

July 25, 2017

Brain Receptor Caught in Action May Help Researchers Find New Huntington’s Treatments

News

A snapshot of a key brain receptor in action might advance the understanding of disease processes in Huntington’s disease and allow scientists to identify new treatments, researchers at Columbia ... Read more

July 20, 2017July 20, 2017

New Research Data Network Aims to Advance Discovery of Huntington’s Treatment

News

Researchers have created the first freely available data network — called HDNetDB — that aims to advance research into Huntington’s disease and speed up drug discovery for the incurable ... Read more

July 18, 2017

Wave Life Sciences to Start Trials of Two Therapies That Target Huntington’s Mutations

News

Wave Life Sciences will start two Phase 1b/2a clinical trials to investigate the safety and tolerability of its products WVE-120101 and WVE-120102 in Huntington’s disease patients. The trials will ... Read more

July 13, 2017

People with Chorea Can Switch from Xenazine To Austedo Safely, Phase 3 Clinical Trial Shows

News

Huntington’s patients who are taking Xenazine for the twitching condition known as chorea can switch without concern to the newly approved Austedo, according to Austedo’s maker, Teva Pharmaceutical Industries. A Phase 3 ... Read more

July 11, 2017

Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms

News

A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated with disease severity in Huntington’s patients, while a higher metabolism ... Read more

July 6, 2017

MSH3 Gene Mutations May Be Involved in Huntington’s Disease Progression, Study Finds

News

Mutations of the MSH3 gene may be associated with the progression of Huntington’s disease, according to a British study. The gene could become a biomarker for the disease, and ... Read more

June 29, 2017

Mitoconix Bio Obtains $20 Million To Continue Developing Huntington’s Therapy MTC-1203

News

Mitoconix Bio has secured $20 million in financing to continue developing MTC-1203 as a treatment for mitochondrial impairment in Huntington’s and Parkinson’s diseases. Several pharmaceutical companies and medical-related venture-capital funds ... Read more