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October 10, 2019October 10, 2019

Short-term Exercise Interventions Do Not Produce Significant Motor Benefits in Huntington’s Patients, Meta-analysis Reports

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A combined data analysis of five studies examining the effects of short-term exercise interventions in Huntington’s disease (HD) did not find any evidence of statistically significant motor improvements. The ... Read more

October 8, 2019October 8, 2019

Study Examines Levels of Trace Metals in Blood of Huntington’s Patients

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Levels of certain trace metals are altered in the blood of people with Huntington’s disease, a new study found, suggesting that measuring and/or targeting these metals may be useful ... Read more

October 3, 2019October 3, 2019

Nmnat Enzyme May Halt Accumulation of Mutant Htt Protein Clumps in Nerve Cells, Study Shows

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Increasing the levels of a natural enzyme called nicotinamide mononucleotide adenylyltransferase — or Nmnat — halts the formation of mutant huntingtin (Htt) protein aggregates that build up in nerves ... Read more

October 1, 2019October 1, 2019

Apathy Linked to Changes in Brain White Matter at Different Huntington’s Stages, Study Finds

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Different types of apathy — a common psychiatric symptom of Huntington’s disease — are associated with specific alterations in the brain’s white matter in patients at different stages of ... Read more

September 26, 2019

NORD 2019 Rare Disease Summit Set for Oct. 21-22 in Washington, DC

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Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board ... Read more

September 26, 2019September 26, 2019

Laquinimod Reduces Signs of Inflammation, Brain Atrophy in Huntington’s, Data Show

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Laquinimod, an experimental immunomodulatory therapy developed by Active Biotech and Teva Pharmaceuticals, reduced signs of inflammation and brain atrophy (shrinkage) in patients with Huntington’s disease, data from an exploratory analysis ... Read more

September 24, 2019September 24, 2019

Huntington’s May Manifest in Early Phases of Embryo Development, Study Finds

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Huntington’s disease may manifest itself for the first time during neurulation, a process in which the neural tube — the precursor of our nervous system (brain and spinal cord) ... Read more

September 20, 2019September 20, 2019

Study Suggests Differences in How Memory Is Used in People with Manifest Huntington’s

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People with Huntington’s disease tend to use their own memories less in engaging with those around them, a new study found. The researchers say a diminished capacity for autobiographical ... Read more

September 17, 2019September 17, 2019

Age of Onset in Huntington’s Linked to Property of CAG Repeat Length in Study

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Age of onset in Huntington’s disease is associated with a property of the inherited CAG repeat length in the huntingtin (HTT) gene — which determines the probability of further repeat ... Read more

September 10, 2019September 10, 2019

New Small Molecule AZ67 May Help Prevent Brain Cell Death, Early Data Show

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A small molecule that alters glucose metabolism in stressed brain cells may help prevent their death, representing a new strategy for treating brain diseases including amyotrophic lateral sclerosis, Alzheimer’s ... Read more

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