Emerald Health Pharmaceuticals announced that two of its cannabinoid-derived candidates — CBGA-Q and CBGA-Q-Na Salt — showed anti-inflammatory and neuroprotective effects in a mouse model of Huntington’s disease. However, these benefits were not superior to those obtained from treatment with the company’s already patented EHP-102 compound. The…

A protein responsible for protecting nerve cells can become embedded in other substances in the brains of  Huntington’s patients, preventing it from performing its neuroprotective work, Spanish researchers report. Another important finding was that the areas where the ATF5 protein are embedded also contain clusters of the faulty huntingtin protein…

Although symptoms of Huntington’s disease don’t appear until later in life, new research suggests that the genetic flaw may alter neurons during early development — findings that may change ideas on how to treat the illness. For the study, “Developmental alterations in Huntington’s disease neural cells and pharmacological…

Caffeine boosts a neuroprotective protein in the brain that is lost in neurodegenerative conditions such as Huntington’s disease, according to a study. Researchers identified 23 other compounds that also act on the protein, known as NMNAT2. Since increasing the protein may help patients with Huntington’s or similar conditions, the researchers…

By using computational modeling, researchers have demonstrated that at the early stages of mutant huntingtin (mHtt) aggregation, a molecular feedback loop works to prevent the effects of the toxic aggregates, until a tipping point is reached. Because the study, “Systemic study of a natural feedback loop in…

Researchers at Massachusetts General Hospital (MGH) report they’ve identified a novel compound that could be a potential therapy strategy for Huntington’s disease, protecting nerve cells from death in both cultured cells and animal models of the disease. The study, “SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in…

NEAT1 (Nuclear Enriched Abundant Transcript 1), a long non-coding RNA molecule, might be protecting neurons in Huntington’s disease (HD) a new study suggests.

Using a fruit fly model of Huntington’s disease (HD), researchers found that curcumin – a substance in the spice turmeric– can reduce neuronal death and dysfunction and lead to better motor function in flies. The findings – in the report “Curcumin modulates cell death and is protective in…