News

A study recently published in the journal Molecular Cell revealed a new role played by polyglutamine repeats in addition to their link to neurodegenerative disorders. The study is entitled “Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity” and was led by researchers at the Katholieke Universiteit (KU)…

In a recent study published in the journal Scientific Reports, researchers showed that a new test developed by a team of researchers at the UBC allows clinicians to quantity the effects of gene silencing therapy for patients with Huntington’s disease (HD) and will support the first…

A groundbreaking research initiative on cell reprogramming for drug development against Huntington’s disease recently received $1.19 million worth of funding for the next 3 years, thanks to the Health Research Council to University of Auckland. Lead investigator and neuroscientist, Associate Professor Bronwen Connor, will attempt to better understand the disease, particularly…

A multi-institutional team with researchers from the Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium recently published in the journal Cell a new breakthrough in Huntington’s disease by identifying new genetic variants that can accelerate or delay symptom onset in patients. The study is entitled “…

In a new study entitled “Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer” researchers determined the structure of a key receptor underlying neurodegenerative diseases, including Parkinson’s disease, and showed how current drugs targeting these receptors and used to treat Parkinson’s can…

In a new study entitled “Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells” researchers showed that providing low-dose radiation to human pluripotent stem cells can enhance gene-editing, allowing a faster and less expensive throughput of edited cells to understand and find the cure for several diseases…

Isis Pharmaceuticals, Inc. a leading company in RNA-targeted drug discovery and development, recently announced they will initiate a new Phase I/IIa clinical trial of ISIS_HTTRx for the treatment of Huntington’s disease (HD). Roche will give Isis a milestone payment of $22 million for the initiation of the trial. The placebo-controlled,…

Fingolimod, a drug often prescribed to patients with Multiple Sclerosis (MS), has found a new application to treat patients with cognitive impairment in Huntington’s Disease. These were the conclusions of a group of researchers at the University of Barcelona (UB) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), who studied…

The Huntington’s Disease Society of America has selected Dr. Neil Aronin, a professor of medicine, to be this year’s recipient of its prestigious Research Award in recognition of his transformative contributions to what is now known about Huntington’s disease, a rare, inherited neurodegenerative condition. Dr. Aronin is currently the chief of…

Researchers from the Scripps Research Institute identified the protein Rhes as a crucial player in neuronal death in the striatum, the brain region responsible for motor and cognitive functions. The study entitled “Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington’s…