Stealth BioTherapeutics has started a Phase 1/2 clinical trial to investigate the safety and effectiveness of SBT-20 in patients with early-stage Huntington’s disease in the Netherlands. SBT-20 was designed to restore the proper activity of mitochondria, the cell’s powerhouses, in Huntington’s patients. Mitochondria organelles become faulty as the disease progresses.
Treatment with Vaccinex’s experimental antibody VX15 was seen to stop loss of brain volume and activity in patients with late prodromal (pre-manifest) and early manifest Huntington’s disease, according to preliminary results of the SIGNAL clinical trial. VX15 is an antibody that inhibits a protein called semaphorin 4D (SEMA4D), which participates…
The latest results on the effectiveness and safety of pridopidine (called Huntexil in Europe) for the treatment of Huntington’s disease (HD) will be presented at the annual meeting of the American Academy of Neurology (AAN) April 22-28 Boston. Pridopidine is an investigational drug that has the potential to…
Pope Francis will meet May 18 in the Vatican with patients and others who are fighting Huntington’s disease in what organizers are billing as the world’s largest gathering ever of the Huntington’s community. The event is part of Huntington’s advocates’ HDennomore global initiative. The phrase, which means Hidden No…
Probiodrug AGÂ recently announced the results of a preclinical study investigating the role of glutaminyl cyclases (QCs) in Huntington’s disease. The results will be presented at the 12th Annual HD Therapeutics Conference of the CHDI Foundation, in Malta, April 24-27. Probiodrug AG is a biopharmaceutical company developing innovative…
A recent report showed that patients with early Huntington’s disease (HD) cannot control their impulsiveness. However, when confronted with a risk-taking situation, they present a similar response as individuals without the disease. Recognizing this behavior pattern can have important implications during treatment and rehabilitation. The study, “Early Huntington’s Disease:…
A virus that delivers UniQure‘s gene therapy candidate AMT-130 has done a good job of getting the Huntington’s disease treatment into the brains of primates, company research shows. Injections of the virus delivered the treatment with precision and without side effects, researchers said. AMT-130’s delivery component is an AAV5 viral vector. AAV5…
Teva Pharmaceutical Industries‘ Austedo tablets have received U.S. approval for treating chorea, or severe movement problems, associated with Huntington’s disease (HD). Austedo (deutetrabenazine, SD-809) is the first deuterated drug the U.S. Food and Drug Administration (FDA) has authorized, and only the second therapy it has approved for Huntington’s. The FDA had…
Huntington’s disease specialist Herwig Lange will give an online presentation Thursday, April 6, on environmental factors that impact the disease’s onset, progression and severity. Patients, caregivers, disease advocates, foundation members and others interested in Huntington’s can register for the free webinar here. The presentation will be titled “Beyond Genetics: The Importance…
Blood samples may be crucial in tracking brain changes that occur in people with Huntington’s disease, a new study finds. Researchers also report that Huntington’s and Alzheimer’s patients have certain inflammatory mechanisms in common, suggesting a potential for shared therapeutic approaches. The study, “Huntington’s disease blood and brain show a common gene expression pattern and share an…
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