News

Electroencephalography (EEG), a noninvasive test of electrical activity in the brain, may be a useful tool to help track disease progression in Huntington’s disease, as patients tend to show certain characteristic abnormalities that are associated with symptom severity. “EEG may serve as a potential biomarker for early diagnosis and…

A new measure, called the Huntington’s Disease-Behavioral Questionnaire (HD-BQ), effectively captures behavioral symptoms in people with Huntington’s disease, as well as differences between patient reports and those of their companions, a study shows. Companions reported more widespread and severe symptoms than patients, particularly in cognitive…

Levels of certain blood markers that are tested as part of routine medical care, such as cholesterol and liver injury indicators, may help predict how fast Huntington’s disease progresses, a new study found. According to the researchers, such routine blood tests “may help anticipating HD [Huntington’s disease] progression.” The…

Genistein, a compound found in soy products, was seen to reduce nerve cell damage and improve motor function and coordination in a mouse model of Huntington’s disease — alongside other benefits, which included extending the animals’ lifespan. That’s according to new research by scientists in the U.S. and…

A small fragment of the huntingtin protein, called HTT1a, may play an important role in the development of Huntington’s disease, the findings of a mouse study suggest. According to the scientists, this protein fragment was seen to trigger the disease in the mice. When researchers blocked the production of…

An interaction between two proteins — one called Rhes and the other Slc4a7 — helps to build tiny tunnels between nerve cells that allow mutant huntingtin protein, the cause of Huntington’s disease, to move from one neuron to another and spread throughout the brain. Those are the findings of…

Roflumilast, an oral therapy approved in the U.S. to treat inflammatory lung disease, was shown to reduce brain inflammation, promote the health of connections between brain cells, and ease symptoms in a rat model of Huntington’s disease. According to the research team, from Cairo University in Egypt, these beneficial…

Women with Huntington’s disease are more likely to experience irritability and to be unemployed or working part-time than men with the neurodegenerative condition, according to a small, single-center study in Austria. Men and women with Huntington’s showed similar genetic burden, age at disease onset, and motor symptom severity, suggesting…

The U.S. Food and Drug Administration (FDA) has asked uniQure to conduct an additional clinical trial before submitting an application seeking approval of its experimental gene therapy, AMT-130, for Huntington’s disease. That’s according to a press release from uniQure announcing the final minutes of a Type A…

Combining pridopidine and FA10, two investigational compounds for Huntington’s disease that target different proteins in the brain, was found to protect against nerve cell death better than either treatment alone. That’s according to a new study that used a cellular model of the genetic disorder to assess the…