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When young, healthy progenitors of neuron-supporting cells called glia are transplanted into the adult brain, they can grow and replace diseased glial cells, including those carrying a Huntington’s disease-causing mutation, a study in mice reports. “These findings have strong therapeutic implications, as they suggest that in the adult human…

What do you say — in under a minute! — to someone about a rare disease? How do you convey the needs of people with Huntington’s disease (HD), knowing how terrible it is because you’ve spent years watching what it does to people you love? How can you explain…

Huntington’s disease could develop at earlier ages in people using calcium channel blockers to control hypertension, a study that looked into genes encoding targets of blood pressure-lowering medications reported. Findings may have important implications for managing high blood pressure in people at risk of Huntington’s, identified before disease…

I love the random questions my wife, Jill, asks me. One such query recently led to a deep and productive conversation. Jill asked me if I thought that anyone could become a good writer. I knew there was a story behind the question, so I asked if she’d share…

It was 6 a.m., time for me to leave for work. I got into my car, pressed down on the brake, and hit the start button. The engine sputtered and then made no sound. Uh-oh. I repeated the steps, but again, there was no comforting “vroom” sound of the engine…

PTC Therapeutics’ Huntington’s disease treatment candidate PTC518 is well-tolerated and lowers blood levels of the huntingtin protein (HTT) in people with the neurodegenerative disorder. That’s according to interim three-month data from the Phase 2a PIVOT-HD trial (NCT05358717), which found that use of the investigational oral therapy did not…

How could a musical lead to tears and a conversation about my wife’s Huntington’s disease (HD)? That was my thought as Jill and I recently walked out of the National Theatre in Washington, D.C., after seeing a former Broadway musical called “Jagged Little Pill,” which was inspired…

The quote that best describes my wife, Jill, is “Hoping for the best, prepared for the worst, and unsurprised by anything in between,” from Maya Angelou‘s “I Know Why the Caged Bird Sings.” When the love of my life started showing early signs of Huntington’s disease (HD)…

A computer-based test called SelfCog, which tests various cognitive functions in a standardized manner, yielded promising results in assessing cognitive decline in people with early-stage Huntington’s disease, a study has found. SelfCog demonstrated sensitivity to detect cognitive decline over a one-year follow-up, outperforming traditional cognitive assessments, and showed associations…

After my beloved wife, Jill, and I left a recent party, she was a little shaken up. When I asked why she was upset, she said, “Do you think love is enough to sustain a marriage?” I said, “Yes, of course.” She said, “Did you know the University of…