Posts by: Jose Marques Lopes, PhD

News

Immunotherapy candidate laquinimod failed to meet its primary objective of improving motor function in Huntington’s disease patients after 12 months of treatment in a Phase 2 clinical trial. However, it did ... Read more

July 18, 2018

Genes Involved in Inflammation, Cellular Structure May Be Therapeutic Targets in Huntington’s

News

Targeting specific genes involved in inflammation and cellular structure may be a therapeutic strategy to reduce protein clumps in patients with Huntington’s disease, according to researchers. Their study, “High-Throughput ... Read more

June 19, 2018June 19, 2018

Defective Protein in Huntington’s Linked to Heart Dysfunction in Mouse Study

News

A key protein in Huntington’s disease has damaging effects on heart function beyond the disease’s devastating neurological impact, according to researchers. Their study, “Cardiac mTORC1 Dysregulation Impacts Stress Adaptation ... Read more

April 26, 2018April 26, 2018

#AAN2018 – Potential Huntington’s Treatment Halts Loss of Brain Volume, Improves Metabolism, Study Finds

News

Treatment with investigational medication VX15/2503 halts disease-related loss of brain volume and improves its metabolic activity in Huntington’s disease patients, according to a Phase 2 clinical study. The research, “Clinical Development ... Read more

March 5, 2018March 5, 2018

Blocking Certain Glutamate Receptors Seen to Ease Huntington’s Advance in Mouse Model of Disease

News

Blocking specific glutamate receptors was seen to improve cellular, motor, and cognitive skills in a mouse model of Huntington’s disease. The study, “mGluR5 antagonism increases autophagy and prevents disease ... Read more

February 1, 2018

Physical Activity May Help Huntington’s Patients, Review Study Finds

News

Exercise and physical activity may benefit patients with Huntington’s disease (HD), a new review study shows. The study, “Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods ... Read more

January 9, 2018January 9, 2018

Endurance Training May Delay Muscular Dysfunction in Huntington’s Patients, Study Shows

News

Huntington’s disease (HD) patients respond to endurance training much like anyone else, by increasing muscular energy metabolism, say Swiss researchers who suggest such training might help delay muscular dysfunction ... Read more

January 2, 2018

Cancer Therapy Bexarotene Shows Early Promise in Treating Huntington’s, Mouse Study Finds

News

Researchers have found that bexarotene, an existing, approved drug used to treat cancer, may also be an effective therapy for Huntington’s disease. The study, “PPARδ activation by bexarotene promotes ... Read more

October 24, 2017

uniQure Gene Therapy Candidate Improves Motor Coordination, Survival in Huntington’s Mice, Study Shows

News

uniQure recently showed that its gene therapy candidate AMT-130 improves motor coordination and survival in mouse models of Huntington’s disease (HD). The preclinical study results were presented at the European ... Read more

Posts by: Jose Marques Lopes, PhD

Jose Marques Lopes, PhD

Laquinimod Fails to Improve Motor Function but Reduces Brain Atrophy in Phase 2 Huntington’s Trial

Genes Involved in Inflammation, Cellular Structure May Be Therapeutic Targets in Huntington’s

Defective Protein in Huntington’s Linked to Heart Dysfunction in Mouse Study

#AAN2018 – Potential Huntington’s Treatment Halts Loss of Brain Volume, Improves Metabolism, Study Finds

Blocking Certain Glutamate Receptors Seen to Ease Huntington’s Advance in Mouse Model of Disease

Physical Activity May Help Huntington’s Patients, Review Study Finds

Endurance Training May Delay Muscular Dysfunction in Huntington’s Patients, Study Shows

Cancer Therapy Bexarotene Shows Early Promise in Treating Huntington’s, Mouse Study Finds

uniQure Gene Therapy Candidate Improves Motor Coordination, Survival in Huntington’s Mice, Study Shows

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