News

Researchers Reverse Huntington’s Defects in Cell Model

Using a new Huntington’s disease model featuring two types of disease affected neurons grown together in the lab, researchers showed that introducing a specific protein part reduced mutant huntingtin, as well as other molecular effects linked to the disease. Findings presented in the study titled “TRiC subunits enhance…

Complexity of Brain Area, Huntington’s Further Revealed in Salk Study

A new study by researchers at the Salk Institute, in California, sheds light on how a major movement center of the brain called the striatum might work. The striatum is involved in several nervous system diseases including Huntington’s disease where neurons in the region progressively degenerate, leading to severe motor and cognitive problems and…

Experimental Therapy Appears to Improve Some Huntington’s Symptoms in Mouse Study

Despite efforts to develop therapies to treat Huntington’s disease (HD), so far no treatment has been shown to effectively stop, slow, or reverse disease progression. Now, an animal study suggests that treating mice with the experimental drug laquinimod can improve some neuropathologic and behavioral features of Huntington’s. The study, titled “Laquinimod…

Researchers Shed Light on Cognitive Problems in Huntington’s Disease, Potentially Leading to Future Therapies

A new study from researchers in Spain may increase understanding of a less recognized aspect of Huntington’s disease (HD): cognitive problems. The article examines the possible causes of cognitive difficulties in HD and how they might be addressed through new therapies. The report, “Cognitive Dysfunction in Huntington’s Disease: Mechanisms and…

Promising Target for Huntington’s Disease Found

In a recent study, the modification of a specific component of the huntingtin protein reduced neurodegenerative symptoms in an animal model’s brain and offered hope for future therapies that could effectively treat Huntington’s disease in humans. The study, “Serine 421 regulates mutant huntingtin toxicity and clearance in mice,” was published in the…