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A combined data analysis of five studies examining the effects of short-term exercise interventions in Huntington’s disease (HD) did not find any evidence of statistically significant motor improvements. The investigators suggest more supervised trials of longer duration and with common outcomes are necessary in order to evaluate the…

Levels of certain trace metals are altered in the blood of people with Huntington’s disease, a new study found, suggesting that measuring and/or targeting these metals may be useful for studying, or perhaps treating, Huntington’s. The results, “Trace elements profile in the blood of Huntington’ disease patients,”…

Increasing the levels of a natural enzyme called nicotinamide mononucleotide adenylyltransferase — or Nmnat — halts the formation of mutant huntingtin (Htt) protein aggregates that build up in nerves cells in Huntington’s disease, a fruit fly study shows. “We discovered the neuroprotective role of a cellular ‘housekeeping’…

Different types of apathy — a common psychiatric symptom of Huntington’s disease — are associated with specific alterations in the brain’s white matter in patients at different stages of the disease, a study finds. White matter refers to regions of the brain made up of myelinated…

Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board of directors. “The pace of discovery in rare diseases has gone from brisk to hypersonic,” Summar told Bionews Services, publisher…

Laquinimod, an experimental immunomodulatory therapy developed by Active Biotech and Teva Pharmaceuticals, reduced signs of inflammation and brain atrophy (shrinkage) in patients with Huntington’s disease, data from an exploratory analysis of a Phase 2 trial show. The new data were presented by Active Biotech in three posters…

Huntington’s disease may manifest itself for the first time during neurulation, a process in which the neural tube — the precursor of our nervous system (brain and spinal cord) — develops while an embryo is forming, scientists report. These findings are in the study “Self-organizing neuruloids…

People with Huntington’s disease tend to use their own memories less in engaging with those around them, a new study found. The researchers say a diminished capacity for autobiographical recollection in these patients may prevent “the benefits of interpersonal bonding.” Titled “Discrete changes in the frequency…

Age of onset in Huntington’s disease is associated with a property of the inherited CAG repeat length in the huntingtin (HTT) gene — which determines the probability of further repeat expansions in nerve cells — rather than with the toxicity of the protein it produces, a study suggests. Along…

A small molecule that alters glucose metabolism in stressed brain cells may help prevent their death, representing a new strategy for treating brain diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Huntington’s disease, among others. The potential therapeutic candidate was described in the journal Scientific Reports…