Malika Ammam, PhD,  —

Researchers at the University of Cambridge, United Kingdom, recently investigated the effect of methamphetamine on the circadian clock of a genetically engineered mouse model of Huntington’s disease (HD) and found that the disruption caused behavioral abnormalities in a gene dose- and age-dependent manner. The study, “Progressive gene dose-dependent disruption…

uniQure recently published results from preclinical studies of its gene therapy program, AMT-130, indicating that a one-time administration of AAV5-delivered therapy into the central nervous system can block the mutant HTT gene that causes Huntington’s disease (HD). These findings, in the article “Design, Characterization, and Lead Selection of Therapeutic miRNAs…

In a recently published paper in the Brain and Behavior journal entitled “Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington’s disease“, French CNRS researchers in collaboration with institutions from Gottingen in Germany, investigated the…

In a recent paper published in Nature Neuroscience journal entitled “Human mutant huntingtin disrupts vocal learning in transgenic songbirds“, Rockefeller University researchers reported that songbirds could be used as new tool to study Huntington’s disease (HD), providing a more complete understanding of the mechanisms underlying brain neurodegeneration.

In a recent study published in Cell Reports entitled “BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear Calcium-induced Transcription of inhba/Activin A“, published in Cell Reports, researchers from Heidelberg University’s Interdisciplinary Center for Neurosciences found that activated neurons produce…