Magdalena Kegel,  —

Magdalena is a writer with a passion for bridging the gap between the people performing research, and those who want or need to understand it. She writes about medical science and drug discovery. She holds an MS in Pharmaceutical Bioscience and a PhD — spanning the fields of psychiatry, immunology, and neuropharmacology — from Karolinska Institutet in Sweden.

Articles by Magdalena Kegel

Prenatal Testing for Huntington’s Should Include Psychological Support, Study Finds

New research from University Hospital Pitié-Salpêtrière at Sorbonne University, France indicates that couples at risk of transmitting Huntington’s disease to their children need more psychological support before pre-natal testing of the embryo’s genetic status, and additional counseling should they choose to reproduce again. In practice, about 5-25% of men and women at risk…

Transplants of Healthy Glial Cell Seen to Prevent Huntington Symptoms in Mice

Groundbreaking research from the University of Copenhagen showed that healthy glial cells, transplanted into the brains of mice in a Huntington’s disease model, improved symptoms and prolonged the animals’ lives, demonstrating that glial cells actively contribute to disease processes — a finding with potentially far-reaching implications for the research into, and treatment…

Kidney Protein Plays Key Role in Brain Axonal Branching

A protein, known for its role in the kidneys, has been identified by University of Louisville scientists as a key player in axonal branching –  a process by which nerve cells extend  processes to connect to other nerve cells. The discovery of the protein’s crucial role will shed light…

Exercise Lowers Brain Glutamate, May Reduce Toxicity

Scientists at the University of Guelph in Canada, have concluded in a recent study, that exercise can increase the use of the neurotransmitter glutamate in the brain, potentially lowering toxicity associated with excessive levels of the compound in neurodegenerative conditions such as Huntington’s disease. Glutamate is one of the…

Huntington’s Neurodegeneration May Be Caused by Rampant Immune Processes

Converging evidence suggests that neurodegenerative conditions, such as Huntington’s disease, are caused by persistent inflammatory immune processes that ultimately kill neurons. This insight, presented by researchers at University of Adelaide, Australia, might change the way researchers approach drug development for neurodegenerative diseases and possibly alter the trajectory of unsuccessful…

Investigational Drug, Olesoxime, Seen to Ease Huntingtin Fragmentation in Mouse Model

Beneficial effects of the investigational neuroprotective drug olesoxime have mainly been attributed to its effects on mitochondria, but new research suggests it also blocks calpain — a molecule directly involved in Huntington’s disease. The findings indicate that exploring the drug’s exact mechanism might bring scientists closer to effective treatments for Huntington’s.

FDA Clears Genetically Engineered Mini Pig Model For Use in Research And Drug Development

Exemplar Genetics announced that the U.S. Food & Drug Administration (FDA) has cleared its low-density lipoprotein receptor (LDLR) mini pig for use in scientific studies. In the future, this type of model could become an invaluable addition to study diseases such as Huntington’s disease, as mouse models have proven insufficient at optimally translating preclinical research…