Posts by: Magdalena Kegel

Magdalena Kegel

Magdalena is a writer with a passion for bridging the gap between the people performing research, and those who want or need to understand it. She writes about medical science and drug discovery. She holds an MS in Pharmaceutical Bioscience and a PhD — spanning the fields of psychiatry, immunology, and neuropharmacology — from Karolinska Institutet in Sweden.

April 6, 2017

Huntington’s Therapy’s Virus Delivery System Works in Primates, Study Shows

News

A virus that delivers UniQure‘s gene therapy candidate AMT-130 has done a good job of getting the Huntington’s disease treatment into the brains of primates, company research shows. Injections of the ... Read more

March 28, 2017March 28, 2017

Huntington’s Disease Neurons May Be Defective from Early Life, Researchers Find

News

Although symptoms of Huntington’s disease don’t appear until later in life, new research suggests that the genetic flaw may alter neurons during early development — findings that may change ideas ... Read more

March 16, 2017March 16, 2017

Loss of Brain Volume Linked to Symptoms Before Huntington’s Diagnosis

News

Changes in brain volume are linked to both movement problems and cognitive decline in people with huntingtin mutations who have not yet received a Huntington’s disease diagnosis, according to ... Read more

March 9, 2017

Caffeine Boosts Neuroprotective Protein Lost in Huntington’s Patients, Study Finds

News

Caffeine boosts a neuroprotective protein in the brain that is lost in neurodegenerative conditions such as Huntington’s disease, according to a study. Researchers identified 23 other compounds that also ... Read more

February 2, 2017

Mitochondrial Energy Processes in Huntington’s May Be Normal After All

News

Mitochondrial abnormalities may not contribute to the degeneration of neurons in the striatum in patients with Huntington’s disease, according to a study that provides evidence contradicting several earlier findings. ... Read more

January 26, 2017

Surveys Explore Huntington’s Patient Perspectives on Symptoms, Treatments

News

Two large surveys that explore the views of adult and juvenile Huntington’s disease patients and their caregivers on symptoms and treatments may help direct research efforts toward issues that ... Read more

December 15, 2016

Numerous DNA Repeats Seen in Huntington’s May be Result of Gene Repair Effort

News

Researchers may finally have tracked down an explanation for expansions of three-letter DNA sequences that disrupt genes, and lead to Huntington’s disease and numerous other neuromuscular and neurodegenerative conditions. The study, “The role ... Read more

December 1, 2016

Muscle Abnormalities Contributed to Huntington’s Disease Symptoms in Mice

News

A study using a mouse model suggests that some symptoms of Huntington’s disease are caused by muscle abnormalities, and are not related to dying neurons. The findings may present ... Read more

November 8, 2016

Investigational Therapy Appears to Prevent Neuron Death, Improve Huntington’s Symptoms in Mice

News

A drug in clinical development by Takeda for schizophrenia, called TAK-063, was seen to reduce neuron death and improve symptoms in mice with Huntington’s disease. But the data needs ... Read more

November 1, 2016

Computational Model Explains How Huntington’s Protective Molecular Path Dead-Ends

News

By using computational modeling, researchers have demonstrated that at the early stages of mutant huntingtin (mHtt) aggregation, a molecular feedback loop works to prevent the effects of the toxic ... Read more