Use of antihypertensives — medications used to treat high blood pressure — is associated with milder disease, slower progression, and delayed clinical onset in people with Huntington’s disease, a study found. The findings suggest an “exciting future avenue to explore the repurposing of specific antihypertensive medications for the…
Researchers have developed a new class of compounds that tackles the root cause of Huntington’s disease, opening up new avenues for the development of novel therapies for the disease. The compounds can lower the levels of mutant huntingtin — the faulty protein in Huntington’s disease — by sending it…
Massive inflammation and other changes in the striatum, an area of the brain selectively destroyed in Huntington’s disease (HD), are already present before patients develop any symptoms, a study has found. These findings could help understand how the disease unravels and…
People at a pre-symptomatic, or premanifest, stage of Huntington’s disease (HD) have subtle speech alterations that may be used as a marker to evaluate new therapies intended to stop or slow disease progression before it becomes too debilitating. The study with that recent research, “…
Measuring the seeding activity of mutant huntingtin (mHTT) protein — its ability to trigger protein aggregation — could be an early biomarker of Huntington’s disease with the potential for monitoring disease onset and progression, according to preclinical findings in mouse and fly models. The study, “mHTT Seeding…
Most people at risk for Huntington’s decide not to undergo genetic testing for the disease due to the lack of effective treatment — and because they can’t unlearn the knowledge that they may have the neurodegenerative disorder, a study shows. Researchers say choosing not to know if one is…
Although many patients with Huntington’s disease (HD) experience pain, they report this problem has less of an effect on their daily lives than it does for the general population, a review study has found. Due to the areas of the brain affected in Huntington’s, patients…
Defects in cells’ “cleaning system,” known as autophagy, may underlie nerve cell degeneration in early stages of Huntington’s disease, according to a recent study. Treatments to improve this process in affected nerve cells could be a promising therapy for Huntington’s and other neurodegenerative diseases. The study,…
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