A Genetic Lottery
— Rebecca Field

A study using a mouse model suggests that some symptoms of Huntington’s disease are caused by muscle abnormalities, and are not related to dying neurons. The findings may present new opportunities for improving patient…

Researchers have identified a new mechanism of cell death in Huntington’s disease called “ballooning cell death” (BCD), according to new research from Tokyo Medical and Dental University. The study, “Targeting TEAD/YAP-Transcription-Dependent Necrosis, TRIAD,…

Huntington’s disease is caused by excessive repeats of a portion of DNA, called CAG triplets, within the gene that codes for huntingtin (HTT). New research shows how the number of CAG repeats determines the final…

Gene therapy biotech uniQure is prioritizing its drug pipeline to develop treatments for Huntington’s disease, hemophilia B, and its partnered gene therapy programs associated with uniQure’s collaboration with Bristol-Myers Squibb (BMS) in cardiovascular disease.

Researchers identified a new molecular mechanism related to mutant huntingtin (HTT) — messenger RNA — that may play a role in the development of Huntington’s disease. This finding may help define new therapeutic approaches to…

Researchers identified several new biomarkers in mice that may help in the early diagnosis of Huntington’s disease in humans, according to a new study. These biomarkers may also be useful to evaluate patients’ responses…

A drug in clinical development by Takeda for schizophrenia, called TAK-063, was seen to reduce neuron death and improve symptoms in mice with Huntington’s disease. But the data needs to be confirmed in other animal…

Critical Path Institute (C-Path) and CHDI Foundation have joined forces to create a consortium geared toward clearly defining regulatory pathways for faster approval of new Huntington’s disease (HD) treatments. The new HD Regulatory Science Consortium…

By using computational modeling, researchers have demonstrated that at the early stages of mutant huntingtin (mHtt) aggregation, a molecular feedback loop works to prevent the effects of the toxic aggregates, until a tipping point…

Researchers at the University of Cambridge, United Kingdom, recently investigated the effect of methamphetamine on the circadian clock of a genetically engineered mouse model of Huntington’s disease (HD) and found that the disruption caused…

An extensive research project has mapped out quality of life issues associated with Huntington’s disease, focusing on matters most important to patients and converting the identified issues into a new “smart” tool that enables patients…

Researchers at the University of Texas identified a potential drug that could be particularly effective in treating Huntington’s disease using a new platform and the microscopic worm Caenorhabditis elegans.