A Genetic Lottery
— Rebecca Field

Levels of a protein called neurofilament light (NFL) could be a valuable biomarker for tracking Huntington’s disease progression, according to a study. The research, “Tau Or Neurofilament Light—Which Is The More Suitable Biomarker For Huntington’s Disease?,” was published…

BRACE, a U.K. charity supporting dementia research, awarded more than £58,500 ($72,631) to a team of scientists investigating how a faulty “recycling” mechanism in neurons contributes to the onset of neurological diseases such as Huntington’s and Alzheimer’s. The winning team…

Researchers discovered new biomarkers of early-stage Huntington’s disease in sheep with the disease, according to a new study. These findings may help detect the disease before symptoms appear, and could aid in the design of new therapies. The study,…

Blocking the expression of mutated huntingtin — the protein involved in Huntington’s disease — by directly targeting the faulty gene may be a way of stopping disease progression in patients, according to results of an early study. The study was published…

NUI Galway researcher and Professor Robert Lahue has been awarded a newly launched grant to investigate potential treatments for Huntington’s disease. The grant is a joint initiative of the Biotechnology and Biological Sciences Research Council UK (BBSRC) and…

Enhancing a cell’s quality control mechanism to get rid of the faulty proteins that are a hallmark of Huntington’s disease may help prevent patients’ motor and cognitive loss, a study suggests. The researchers’ discovery of how the quality control mechanism…

Patients with Huntington’s disease with low levels of perceived psychological distress may have weaker social cognitive skills, according to a new study. However, researchers think that this association (self-reporting of psychological distress and social cognitive test performance) may be due…

The European Union is inviting researchers in 20 countries to work together on projects focusing on Huntington’s disease (HD) and other degenerative diseases. The agency sponsoring the effort, the Joint Programme — Neurodegenerative Disease Research (JPND), said in a press…

Mitochondrial abnormalities may not contribute to the degeneration of neurons in the striatum in patients with Huntington’s disease, according to a study that provides evidence contradicting several earlier findings. The study explored mitochondrial processes in a mouse model of…

A patent application for Vybion’s potential gene therapy for Huntington’s disease (HD) and other neurodegenerative conditions has been granted Track One status by the U.S. Patent and Trademark Office (USPTO). Patent applications are ordinarily reviewed in the…

Two large surveys that explore the views of adult and juvenile Huntington’s disease patients and their caregivers on symptoms and treatments may help direct research efforts toward issues that matter most to those affected. Interestingly, the symptom-focused survey revealed…

A subtype of brain cells called astrocytes could be contributing to the death of neurons in neurodegenerative diseases such as Huntington’s disease (HD), according to a new study published in the leading scientific journal Nature. This new finding presented in a report titled “Neurotoxic reactive astrocytes are induced by activated microglia” is important because it provides opportunities for scientists to develop new treatment approaches to treat Huntington’s and other neurodegenerative diseases.