A Genetic Lottery
— Rebecca Field

Researchers at the University of California and the Salk Institute for Biological Studies have identified the mechanisms that make the brain’s immune cells different from all other immune cells A finding with implications for Huntington’s disease was that genes…

Abnormal proteins found in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s seem to rely on the same mechanism to spread within the brain and disrupt its normal functions, according to a study published in the journal Acta Neuropathologica.

A team of researchers has discovered new insights into cell processes that have gone awry in Huntingon’s disease (HD) patients. This discovery could point scientists toward a potential method of interfering with those processes. The study, “KEAP1-modifying small molecule…

Researchers at the Sussex Drug Discovery Centre in Brighton, England, have received a £3 million grant from Britain’s non-profit Wellcome Trust to develop Huntington’s disease treatments. The team will team up with other researchers to target a protein that plays a…

Researchers have discovered why Huntington’s disease (HD) patients have defects in the blood-brain barrier that contribute to the symptoms of this neurological disorder. Their study, “Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier…

WAVE Life Sciences’ products WVE-120101 (SNP-1) and WVE-120102 (SNP-2) will enter clinical trials in mid-2017 as part of the effort to develop new treatments for patients with Huntington’s disease. “2017 will be an important year for WAVE as we…

Taube Philanthropies has donated $3 million to fund a research team using gene editing and stem cell techniques to develop treatments for Huntington’s disease. The team is composed of Dr. Matthew Porteus and Dr. Frank Longo of Stanford Medicine, and…

Disruption in the trafficking of molecules in and out of the cell’s nucleus may contribute to the pathology of Huntington’s disease, according to results of recent research. The study “Mutant Huntingtin Disrupts The Nuclear Pore Complex” was published in…

Stealth BioTherapeutics has started a Phase 1/2 clinical trial to investigate the safety and effectiveness of SBT-20 in patients with early-stage Huntington’s disease in the Netherlands. SBT-20 was designed to restore the proper activity of mitochondria, the cell’s powerhouses,…

Treatment with Vaccinex’s experimental antibody VX15 was seen to stop loss of brain volume and activity in patients with late prodromal (pre-manifest) and early manifest Huntington’s disease, according to preliminary results of the SIGNAL clinical trial. VX15 is an…

The latest results on the effectiveness and safety of pridopidine (called Huntexil in Europe) for the treatment of Huntington’s disease (HD) will be presented at the annual meeting of the American Academy of Neurology (AAN) April 22-28…

Pope Francis will meet May 18 in the Vatican with patients and others who are fighting Huntington’s disease in what organizers are billing as the world’s largest gathering ever of the Huntington’s community. The event is part of Huntington’s…