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Huntington’s Disease and Its Troubling Weight Loss Studied

A recent study explored the association between gastric mucosa (mucus lining) abnormalities in Huntington’s Disease (HD) and mechanisms in the increased weight loss experienced by HD patients.  The study, entitled, “Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington’s Disease,” was published in the journal…

Huntington’s Gene Produces Cocktail of Mutant RAN Proteins

A group of researchers from the University of Florida Health have discovered new information about Huntington’s disease, namely that the gene causing this severe disorder causes an unforeseen accumulation of “cocktails” of mutant proteins (RAN proteins) in the brain. These newly identified mutant proteins damage neurons and build up in areas…

Potential Treatment Prototype for Taupathies and Neurodegenerative Brain Diseases Under Development

Researchers at the German Center for Neurodegenerative Diseases (DZNE) in Bonn have tested a new substance that may lead to a prototype for the development of drugs to treat Alzheimer’s disease and other tauopathies, including Huntington’s disease. The substance, anle138b, improved symptoms in mice and showed an improvement in their cognition,…

FDA Seeks Input on Huntington’s, Parkinson’s Disease Impact, Treatment

In 2013, the U.S. Food and Drug administration (FDA) selected Huntington’s disease (HD) and Parkinson’s disease (PD) as the focus of a three-year public consultation project for Patient-Focused Drug Development. This initiative involves working toward a better understanding of patient perspectives on the severity of these diseases and evaluation of…

Novel HD Study Zooms in on Peripheral Immune Dysfunction

A new study entitled “Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington’s Disease T Lymphocytes,” published in PLOS ONE, has revealed important insights into future Huntington’s disease therapies aimed at modulating the peripheral immune system, mainly by targeting hyper-reactive monocytes and macrophages.

Huntington’s Patients Often Also Suffer from Psychiatric Disorders

Psychiatric manifestations develop more often than previously thought in Huntington’s disease prodrome, according to findings of a recent study published in The American Journal of Psychiatry. Moreover, it appears that symptoms also increase with disease severity. Early features of Huntington’s disease can include personality changes, mood swings,…

Huntingtin Protein Study Offers New Insights into Mystery of Huntington’s Disease

University of Buffalo researchers have discovered that Huntingtin protein (Htt) is involved in the transport of Rab proteins, which are essential for normal cell function, a discovery that might lead to a greater understanding of the mechanisms behind Huntington’s disease. The research paper entitled “Huntingtin differentially regulates the axonal transport of a sub-set…