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By using computational modeling, researchers have demonstrated that at the early stages of mutant huntingtin (mHtt) aggregation, a molecular feedback loop works to prevent the effects of the toxic aggregates, until a tipping point is reached. Because the study, “Systemic study of a natural feedback loop in…

Researchers at the University of Cambridge, United Kingdom, recently investigated the effect of methamphetamine on the circadian clock of a genetically engineered mouse model of Huntington’s disease (HD) and found that the disruption caused behavioral abnormalities in a gene dose- and age-dependent manner. The study, “Progressive gene dose-dependent disruption…

An extensive research project has mapped out quality of life issues associated with Huntington’s disease, focusing on matters most important to patients and converting the identified issues into a new “smart” tool that enables patients to easily communicate their concerns with physicians. The project, funded by the National Institutes of…

Researchers at the University of Texas identified a potential drug that could be particularly effective in treating Huntington’s disease using a new platform and the microscopic worm Caenorhabditis elegans.

The CHDI Foundation, a privately-funded nonprofit research organization dedicated to fighting Huntington’s disease, has awarded a research grant to a team of scientists from the University of Rochester Medical Center (URMC) to study the role of specific cells in the development of the disease. Dr. Steve Goldman, MD, PhD, co-director…

Abnormal energy production may contribute to the progression of Huntington’s disease, according to a new study. The study, entitled “The Phasor-FLIM Fingerprints Reveal Shifts From OXPHOS To Enhanced Glycolysis In Huntington Disease,” was recently published in the journal Scientific Reports. The mechanisms underlying neurodegeneration in Huntington’s disease remain…

Progressive neurological diseases, such as Huntington’s disease, are associated with pathological changes in the retina and the brain. According to Henri Leinonen from the University of Eastern Finland (UEF) and colleagues, such disorders might be detected earlier by using simple and non-invasive eye examination techniques. In the study “Early…

A survey of 1,700 Huntington’s disease patients that questioned issues such as symptoms, treatment, and disease management, revealed some surprising facts that can impact how physicians and researchers view and treat the condition. Particularly, the survey revealed that patients often lack support during the diagnostic process. GeneFo is an…

A recent review summarizes the scientific literature on behavioral and psychiatric symptoms of Huntington’s disease, noting that plenty of research is still needed to better understand and treat such symptoms, which traditionally have taken second stage to the disease’s movement problems. The review, “Changes in mental state…

Researchers have developed a new gene-editing tool that may improve the precision of future gene therapy efforts in Huntington’s disease, as well as numerous other genetic conditions. The study, “A chemical-inducible CRISPR–Cas9 system for rapid control of genome editing,” published in the journal Nature Chemical Biology,…