Marisa Wexler, MS,  senior science writer—

Treatment with a nonhallucinogenic psychedelic compound may help to ease depression in people with Huntington’s disease, according to experiments done in a mouse model. The research was done by Kaleigh Hanley, a scientist at the University of Central Florida’s College of Medicine. Hanley is one of the recipients of…

People affected by Huntington’s disease often experience stigma, but — according to two social workers, and patients themselves — this can be combated by building loving communities and being proactive about sharing experiences and asking for support. At the 40th annual convention of the Huntington’s Disease Society of…

The Huntington’s Disease Society of America (HDSA) is pushing to get 10 bills that could help provide support for people with Huntington’s disease passed in the U.S. Congress. The nonprofit is also advocating against changes to Medicaid that are currently being considered as part of the 2025 budget…

Today kicks off the 40th annual convention of the Huntington’s Disease Society of America (HDSA), an event the association says provides an opportunity for the Huntington’s disease community to come together to “learn, share, and build hope for the future.” This year’s convention is taking place in…

The Huntington’s Disease Digital Motor Score (HDDMS), a new measure based on four motor tests that are done through a smartphone app, may be able to detect Huntington’s disease progression with greater sensitivity than current standard tools, a study reports. “Our findings suggest that incorporating the HDDMS in clinical trials…

One year of treatment with PTC518 safely lowered blood levels of huntingtin, the protein that’s faulty in Huntington’s disease, in a dose-dependent manner in people with early- and late-intermediate stages of the neurodegenerative condition. That’s according to new data from the Phase 2 PIVOT-HD clinical trial (NCT05358717), which…

Researchers were able to promote the formation of new neurons that integrated into existing motor circuits and helped repair damage and influence motor behavior in the brain of a mouse model of Huntington’s disease, a study showed. “Our research shows that we can encourage the brain’s own cells to…

Mental health problems are common in Huntington’s disease, but there isn’t much data on patients’ use of psychiatric medications, a review study reports. “Although [neuropsychiatric problems] in [Huntington’s disease] are common, hardly any clinical trials have addressed their treatment,” the study’s researchers wrote. “As a result, evidence that…

LETI-101, an experimental gene-editing therapy for Huntington’s disease, showed promising proof-of-concept effects in mouse and cell models by reducing levels of the disease-causing mutant huntingtin (HTT) protein, while preserving HTT’s healthy version. In nonhuman primates, the therapy showed good safety and distribution across brain regions profoundly impacted by Huntington’s. The…

Specific genes involved in repairing mismatched DNA contribute to the development of Huntington’s disease by driving fast somatic CAG repeat expansion — a phenomenon in which Huntington’s-causing mutations grow, or expand, during a person’s lifetime, scientists report. Their study, done in a mouse model of Huntington’s, showed that targeting…