Targeting the Gpr52 receptor can reduce the levels of mutant huntingtin (HTT) proteins and improve Huntington’s disease symptoms, including walking problems, in animal models, a study suggests. The study, ... Read more
Blocking specific glutamate receptors was seen to improve cellular, motor, and cognitive skills in a mouse model of Huntington’s disease. The study, “mGluR5 antagonism increases autophagy and prevents disease ... Read more
Researchers have found that bexarotene, an existing, approved drug used to treat cancer, may also be an effective therapy for Huntington’s disease. The study, “PPARδ activation by bexarotene promotes ... Read more
uniQure recently showed that its gene therapy candidate AMT-130 improves motor coordination and survival in mouse models of Huntington’s disease (HD). The preclinical study results were presented at the European ... Read more
Mitochondrial abnormalities may not contribute to the degeneration of neurons in the striatum in patients with Huntington’s disease, according to a study that provides evidence contradicting several earlier findings. ... Read more
NEAT1 (Nuclear Enriched Abundant Transcript 1), a long non-coding RNA molecule, might be protecting neurons in Huntington’s disease (HD) a new study suggests.
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