disease progression

July 11, 2017

Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms

A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated with disease severity in Huntington’s patients, while a higher metabolism ... Read more

July 6, 2017

MSH3 Gene Mutations May Be Involved in Huntington’s Disease Progression, Study Finds

News

Mutations of the MSH3 gene may be associated with the progression of Huntington’s disease, according to a British study. The gene could become a biomarker for the disease, and ... Read more

June 22, 2017June 22, 2017

Researchers Identify Variant in MSH3 Gene Related to Huntington’s Progression

News

Researchers have identified a variant in the gene MSH3 that is linked with Huntington’s disease (HD) progression. The study, “Identification of genetic variants associated with Huntington’s disease progression: a ... Read more

June 8, 2017

Cell Transport ‘Traffic Jam’ Caused by Mutated Protein, Researchers Discover

News

A mutated form of the huntingtin (mHTT) protein has been acknowledged as the cause of Huntington’s disease, but researchers have not been fully clear about how it disrupts the ... Read more

March 7, 2017March 7, 2017

Levels of NFL Protein Could Help Track Huntington’s Progression, Study Suggests

News

Levels of a protein called neurofilament light (NFL) could be a valuable biomarker for tracking Huntington’s disease progression, according to a study. The research, “Tau Or Neurofilament Light—Which Is ... Read more

February 23, 2017

Researchers Identify New Biomarkers of Early Stage Huntingon’s in Sheep Study

News

Researchers discovered new biomarkers of early-stage Huntington’s disease in sheep with the disease, according to a new study. These findings may help detect the disease before symptoms appear, and ... Read more

February 21, 2017February 21, 2017

Targeting Faulty HTT Gene with Antisense Oligonucleotide May Be Way of Stopping Huntington’s Progression

News

Blocking the expression of mutated huntingtin — the protein involved in Huntington’s disease — by directly targeting the faulty gene may be a way of stopping disease progression in patients, according ... Read more

December 22, 2016

Judgment Task, Called Reversal Learning, Diminishes as Huntington’s Advances, Study Suggests

News

The ability to apply reversal learning, which involves adapting behavior according to changes in stimulus-reward situations, appears to be diminished in patients with Huntington’s disease and to worsen as the disease progresses, ... Read more

December 20, 2016

Co-enzyme Q10 Does Not Delay Huntington’s Disease Progression, Study Shows

News

Taking high doses of co-enzyme Q10 in the early stages of Huntington’s disease does not delay its progression, according to a clinical trial. The study, “A Randomized, Double-Blind, Placebo-Controlled ... Read more