disease progression

October 18, 2018October 18, 2018

Advanced Huntington’s Patients Have Marked Difficulties in Driving, Study Shows

News

Patients at advanced stages of Huntington’s disease have marked difficulties in controlling vehicles in a driving simulator compared to patients who are at a pre-symptomatic stage or healthy subjects, ... Read more

September 6, 2018September 6, 2018

Time Perception Impaired in Huntington’s Patients, and Linked to Disease Severity, Study Finds

News

Time perception is impaired in patients with Huntington’s disease, even in pre- or early-symptomatic stages of the disease, and is correlated with disease severity and progression, Swiss researchers found. ... Read more

June 28, 2018June 28, 2018

Experts Seeking Tools to Assess Effectiveness of Targeted Huntington’s Therapies

News

Improved measures to accurately determine the effectiveness of treatments targeting Huntington’s disease are necessary, according to clinical neurologists and Huntington’s specialists. The editorial, “Improved metrics for Huntington’s disease trials,” ... Read more

February 27, 2018February 27, 2018

Huntington’s Patients’ Skin Cells Transformed Into Nerve Cells That Mimic Disease Symptoms

News

Nerve cells that mimic the molecular features of Huntington’s disease have been created from patients’ skin cells, researchers said. The study, “Striatal neurons directly converted from Huntington’s disease patient ... Read more

February 7, 2018February 8, 2018

Link Between Exact Mutation and Huntington’s Progression May Aid in Early Prognosis, Report Suggests

News

A case study has reported an association between an exact genetic mutation and Huntington’s disease prognosis, which may help tailor treatments at early stages of the disease. Huntington’s disease ... Read more

December 14, 2017

Researchers Review Role of Manganese in Huntington’s Disease Development

News

The chemical compound manganese (Mn) has been reported to take part in the underlying mechanism of Alzheimer’s disease. However, little is known about its involvement in the development of ... Read more

December 5, 2017December 5, 2017

Activity and Levels of Enzyme Aco2 May Be Biomarker of Huntington’s Progression, Early Study Reports

News

A poorly active enzyme called aconitase 2 (Aco2), found at low levels in cells, can be a marker of the mitochondrial dysfunction linked to Huntington’s disease and its progression, ... Read more

October 3, 2017October 3, 2017

Measuring PFS Outcome Might Help Researchers Evaluate Huntington’s Progression, Study Suggests

News

Identifying Huntington’s disease progression can be a challenge in clinical trials. Now, an international team of researchers proposes in an article published in JAMA Neurology the use of a new ... Read more

August 22, 2017August 22, 2017

Identification of Huntington’s Disease Progression Gene Raises Hope of New Treatments

News

Researchers in England and Wales have identified a gene linked to disease progression in Huntington’s disease, shedding new light on the poorly understood mechanisms that cause the disorder. Although ... Read more

July 11, 2017

Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms

News

A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated with disease severity in Huntington’s patients, while a higher metabolism ... Read more

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