News

July 27, 2017

Reducing HDAC3 Protein Levels Can Stop Cognitive Decline Associated with Huntington’s Disease, Study Says

Therapies aimed at reducing the levels of a protein called HDAC3 may improve cognitive decline in Huntington’s disease, according to the results of a new study. The study titled, ... Read more

July 25, 2017

Brain Receptor Caught in Action May Help Researchers Find New Huntington’s Treatments

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A snapshot of a key brain receptor in action might advance the understanding of disease processes in Huntington’s disease and allow scientists to identify new treatments, researchers at Columbia ... Read more

July 20, 2017July 20, 2017

New Research Data Network Aims to Advance Discovery of Huntington’s Treatment

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Researchers have created the first freely available data network — called HDNetDB — that aims to advance research into Huntington’s disease and speed up drug discovery for the incurable ... Read more

July 18, 2017

Wave Life Sciences to Start Trials of Two Therapies That Target Huntington’s Mutations

News

Wave Life Sciences will start two Phase 1b/2a clinical trials to investigate the safety and tolerability of its products WVE-120101 and WVE-120102 in Huntington’s disease patients. The trials will ... Read more

July 13, 2017

People with Chorea Can Switch from Xenazine To Austedo Safely, Phase 3 Clinical Trial Shows

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Huntington’s patients who are taking Xenazine for the twitching condition known as chorea can switch without concern to the newly approved Austedo, according to Austedo’s maker, Teva Pharmaceutical Industries. A Phase 3 ... Read more

July 11, 2017

Metabolic Changes in Certain Brain Regions May Be Associated with Huntington’s Motor Symptoms

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A sluggish metabolism in the cells of the striatum, a brain region essential for motor function control, is associated with disease severity in Huntington’s patients, while a higher metabolism ... Read more

July 6, 2017

MSH3 Gene Mutations May Be Involved in Huntington’s Disease Progression, Study Finds

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Mutations of the MSH3 gene may be associated with the progression of Huntington’s disease, according to a British study. The gene could become a biomarker for the disease, and ... Read more

June 29, 2017

Mitoconix Bio Obtains $20 Million To Continue Developing Huntington’s Therapy MTC-1203

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Mitoconix Bio has secured $20 million in financing to continue developing MTC-1203 as a treatment for mitochondrial impairment in Huntington’s and Parkinson’s diseases. Several pharmaceutical companies and medical-related venture-capital funds ... Read more

June 27, 2017June 27, 2017

Ionis Completes Patient Enrollment in Phase 1/2a Trial of Ionis-HTTRx for Huntington’s Disease

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Ionis Pharmaceuticals has completed enrollment of the Phase 1/2a study evaluating the safety, tolerability, properties and movement within the body of Ionis-HTTRx in patients with Huntington’s disease (HD). Patients ... Read more

June 22, 2017June 22, 2017

Researchers Identify Variant in MSH3 Gene Related to Huntington’s Progression

News

Researchers have identified a variant in the gene MSH3 that is linked with Huntington’s disease (HD) progression. The study, “Identification of genetic variants associated with Huntington’s disease progression: a ... Read more