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August 21, 2018August 21, 2018

Defects in Cells’ ‘Cleaning System’ May Underlie Huntington’s, Researchers Say

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Defects in cells’ “cleaning system,” known as autophagy, may underlie nerve cell degeneration in early stages of Huntington’s disease, according to a recent study. Treatments to improve this process in affected nerve cells ... Read more

August 16, 2018August 16, 2018

Early White Matter Alterations Are Clinically Relevant in Huntington’s Patients, Study Shows

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Changes in the brain’s white matter in early Huntington’s disease can reflect a process that’s clinically relevant and might be linked to early cognitive dysfunction, according to researchers from Harvard ... Read more

August 14, 2018August 14, 2018

Experimental Huntington’s Treatment Improves Memory, Other Brain Functions in Mouse Study

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An investigational compound called VU0409551 could reverse memory deficiencies and improve learning, according to the results of a mouse study in Huntington’s disease. The study, “The mGluR5 positive allosteric modulator VU0409551 ... Read more

August 9, 2018August 9, 2018

Laquinimod Fails to Improve Motor Function but Reduces Brain Atrophy in Phase 2 Huntington’s Trial

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Immunotherapy candidate laquinimod failed to meet its primary objective of improving motor function in Huntington’s disease patients after 12 months of treatment in a Phase 2 clinical trial. However, it did ... Read more

August 7, 2018September 21, 2018

PRIME Designation Should Help Promising Experimental Therapy Reach Huntington’s Patients Faster

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The European Medicines Agency (EMA) has granted Priority Medicine (PRIME) designation to Roche’s investigational therapy RG6042 for the treatment of Huntington’s disease. PRIME provides a pathway for expedited assessment ... Read more

August 2, 2018August 2, 2018

Protein May Help Prevent Nerve Cell Death in Huntington’s Disease

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Researchers have found a protein, called UBR5, that may reduce neurodegeneration in Huntington’s disease (HD). This protein prevents the toxic aggregation (clustering) of mutant huntingtin protein, which is the underlying ... Read more

July 31, 2018July 31, 2018

Damage to Nuclear DNA Shown to Correlate with Huntington’s Duration, Patient’s Ability to Function

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The level of damage present in the DNA inside the cell nucleus — called nuclear DNA — correlates with disease duration and functional capacity in patients with Huntington’s disease, suggesting its potential ... Read more

July 25, 2018

Phase 2a Trial Investigates BP Medicine SOM3355 as Treatment for Chorea

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SOM3355 — a medicine approved for high blood pressure and chest pain — is being tested in a Phase 2 trial as a means to treat chorea in Huntington’s disease patients, SOM ... Read more

July 18, 2018

Genes Involved in Inflammation, Cellular Structure May Be Therapeutic Targets in Huntington’s

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Targeting specific genes involved in inflammation and cellular structure may be a therapeutic strategy to reduce protein clumps in patients with Huntington’s disease, according to researchers. Their study, “High-Throughput ... Read more

July 12, 2018July 12, 2018

Retrotope’s RT001 Reduced Cognitive Defects in Mice with Huntington’s Disease, Study Shows

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Retrotope’s investigative therapy RT001 reduced cognition deficits in mice with Huntington’s disease, and was found to lower the amount of oxidative damage in their brains. The study, “Deuterium‐reinforced linoleic acid lowers lipid peroxidation ... Read more

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