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December 5, 2019December 5, 2019

Early Study Identifies 3 Small Molecules That Target Root Cause of Huntington’s

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Researchers have identified three new small molecules that significantly reduce the formation of toxic aggregates of mutant huntingtin — the underlying cause of Huntington’s disease — in cells derived ... Read more

December 3, 2019December 3, 2019

DEA Clears Way for MMJ to Import Cannabis Compounds for Trials in Huntington’s Disease and MS

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MMJ International Holdings, a pharmaceutical company focused on the development of cannabis-based therapeutic products, will soon begin testing its oral cannabidiol (CBD) and tetrahydrocannabinol (THC) products in U.S. clinical ... Read more

November 21, 2019November 21, 2019

Early Study Finds Huntingtin-lowering Compounds That Show Therapeutic Potential

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Researchers have developed a new class of compounds that tackles the root cause of Huntington’s disease, opening up new avenues for the development of novel therapies for the disease. ... Read more

November 14, 2019November 14, 2019

Mini Pig Model of Huntington’s May be Advantageous in Preclinical Trials, Researchers Say

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The mini pig model of Huntington’s disease not only has a similar brain anatomy to humans, but also shows the slow and age-dependent neurodegeneration and weight loss that’s characteristic ... Read more

November 13, 2019

Rare Disease Film Festival Highlights Patient and Researcher Unity

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Rare disease-themed videos glowed on a large screen before an audience of people in wheelchairs, with crutches, and bearing oxygen tanks this Nov. 9 and 10 in San Francisco. ... Read more

November 13, 2019November 14, 2019

Q-Motor Tool Shows Promise in Detecting Motor Changes in At-risk Children, Study Shows

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Q-Motor, a promising motor-assessment tool for adults with Huntington’s disease, also provides non-invasive, easy, and sensitive measures to gauge motor function changes in children and adolescents, a study shows. The ... Read more

November 7, 2019November 7, 2019

Nerve Cell Development Appears Delayed in Juvenile Huntington’s, Stem Cell Study Reports

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Stem cells created from cells taken from juvenile Huntington’s disease (JHD) patients showed a delay in developing into mature neurons, but one that is reversible, a study reports. The study, ... Read more

November 5, 2019November 5, 2019

Microprotein of Mitochondria Helps Regulate Protein Folding and Cell Stress Linked to Disease, Study Finds

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PIGBOS — a newly discovered mitochondrial microprotein involved in a cellular stress-response mechanism called unfolded protein response (UPR) — might be a treatment target for neurodegenerative diseases like Huntington’s, a ... Read more

October 31, 2019October 31, 2019

MC10 and University of Vermont Establish Partnership to Study Gait Impairment in Huntington’s, other Movement Disorders

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MC10 and the University of Vermont have teamed up to advance understanding of gait impairments in Huntington’s disease and other movement disorders. The partnership will combine MC10’s BioStamp nPoint ... Read more

October 29, 2019October 29, 2019

Inflammation and Changes in Brain’s Striatum Precede Huntington’s Symptoms, Study Finds

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Massive inflammation and other changes in the striatum, an area of the brain selectively destroyed in Huntington’s disease (HD), are already present before patients develop any symptoms, a study ... Read more

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