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October 29, 2019October 29, 2019

Inflammation and Changes in Brain’s Striatum Precede Huntington’s Symptoms, Study Finds

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Massive inflammation and other changes in the striatum, an area of the brain selectively destroyed in Huntington’s disease (HD), are already present before patients develop any symptoms, a study ... Read more

October 24, 2019October 24, 2019

Length of CAG Repeats in HTT Gene Expand with Age, Linked to Worse Clinical Outcomes, Study Finds

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The length of CAG repeats within the huntingtin (HTT) gene tends to increase as people with Huntington’s disease get older and is directly correlated with poor clinical outcomes, a ... Read more

October 22, 2019October 22, 2019

Psychosis Linked to More Severe Cognitive, Functional and Behavioral Symptoms, But Less Chorea, Study Finds

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People with Huntington’s disease who develop psychosis tend to have worse cognitive and behavioral disturbances, reduced ability to function, and fewer involuntary movements than patients who do not experience ... Read more

October 17, 2019October 17, 2019

Handwriting Can Help Identify Asymptomatic Huntington’s, Study Suggests

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Analysis of handwriting movements using a pen tablet and specialized software can accurately distinguish people with Huntington’s disease who are still asymptomatic from those without the disease, a new ... Read more

October 15, 2019October 15, 2019

Mutations Linked to Huntington’s Increase Nerve Cells’ Resistance to High Levels of Manganese, Study Finds

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Mutations associated with Huntington’s disease increase nerve cells’ resistance to high levels of manganese, according to a recent study. The results of the study, “Huntington’s disease associated resistance to ... Read more

October 10, 2019October 10, 2019

Short-term Exercise Interventions Do Not Produce Significant Motor Benefits in Huntington’s Patients, Meta-analysis Reports

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A combined data analysis of five studies examining the effects of short-term exercise interventions in Huntington’s disease (HD) did not find any evidence of statistically significant motor improvements. The ... Read more

October 8, 2019October 8, 2019

Study Examines Levels of Trace Metals in Blood of Huntington’s Patients

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Levels of certain trace metals are altered in the blood of people with Huntington’s disease, a new study found, suggesting that measuring and/or targeting these metals may be useful ... Read more

October 3, 2019October 3, 2019

Nmnat Enzyme May Halt Accumulation of Mutant Htt Protein Clumps in Nerve Cells, Study Shows

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Increasing the levels of a natural enzyme called nicotinamide mononucleotide adenylyltransferase — or Nmnat — halts the formation of mutant huntingtin (Htt) protein aggregates that build up in nerves ... Read more

October 1, 2019October 1, 2019

Apathy Linked to Changes in Brain White Matter at Different Huntington’s Stages, Study Finds

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Different types of apathy — a common psychiatric symptom of Huntington’s disease — are associated with specific alterations in the brain’s white matter in patients at different stages of ... Read more

September 26, 2019

NORD 2019 Rare Disease Summit Set for Oct. 21-22 in Washington, DC

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Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board ... Read more

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