Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms of mutated huntingtin are actually responsible for major molecular changes ... Read more
Scientists at the University of Guelph in Canada, have concluded in a recent study, that exercise can increase the use of the neurotransmitter glutamate in the brain, potentially lowering ... Read more
A protein responsible for protecting nerve cells can become embedded in other substances in the brains of Huntington’s patients, preventing it from performing its neuroprotective work, Spanish researchers report. ... Read more
Researchers have identified an elaborate protein quality control system that prevents toxic accumulation of faulty proteins inside mitochondria, a phenomenon that underlies many neurodegenerative diseases, including Huntington’s disease. The ... Read more
Researchers used gene editing to suppress the activity of protein mutations in the brains of mice with Huntington’s disease. Suppressing the huntingtin protein alleviated early signs of the disease ... Read more
Inhibiting the activity of an enzyme preserved the movement capabilities of mice with Huntington’s, slowed the progression of the disease and extended the animals’ lives, according to a study. ... Read more
Probiodrug AG recently announced the results of a preclinical study investigating the role of glutaminyl cyclases (QCs) in Huntington’s disease. The results will be presented at the 12th Annual HD ... Read more
Researchers at the University of Texas identified a potential drug that could be particularly effective in treating Huntington’s disease using a new platform and the microscopic worm Caenorhabditis elegans.